Cd2 Rat Monoclonal Antibody [Clone ID: 12-15]

CAT#: AM08025BT-N

Cd2 rat monoclonal antibody, clone 12-15, Biotin

Specifications

Product Data

• Clone Name: 12-15
• Applications: FC, FN, IP
• Recommended Dilution: Flow Cytometry < / = 1 µg/10e6 cells. (Ref.1-3)
  Immunoprecipitation. (Ref.1-2)
  Functional Assay:
  In vitro Inhibition of CTL-mediated lysis. (Ref.1)
  Induction of T cell unresponsiveness in vivo. (Ref.4)
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody is specific to CD2/LFA-2 (Mr 45-58 kDa)
• Formulation: PBS containing 0.09% Sodium Azide as preservative.
  Label: Biotin
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD2 antigen
• Database Link:
  Entrez Gene 12481 Mouse
  UniProt ID P08920
• Background: CD2, also known as leukocyte function-associated antigen-2 (LFA-2), is a member of the immunoglobulin superfamily of cell adhesion molecules. (Ref.1) It is expressed on the surface of >95% of thymocytes, and essentially all B cells, T cells and NK cells. (Ref.1-3) In the mouse, CD2 is the receptor for CD48. (Ref.4) CD2 is thought to play a major role in mediating T-cell adhesion, T-cell recognition/activation, T-cell signaling and intrathymic differentiation. (Ref.5-10)
• Synonyms: SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor