SNAIL (SNAI1) Mouse Monoclonal Antibody [Clone ID: 6D2]

CAT#: AM06589SU-N

SNAIL (SNAI1) mouse monoclonal antibody, clone 6D2, Ascites

Product Images

Western blot analysis using SNAI1 antibody Cat.-No AM06589SU-N against human SNAI1 (AA: 2-264) recombinant protein (Expected MW is 31.3 kDa)

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  Western blot analysis using SNAI1 antibody Cat.-No AM06589SU-N against NTERA-2 cell lysate.

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Specifications

Product Data

• Clone Name: 6D2
• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human SNAI1 expressed in E. Coli.
• Specificity: Recognizes SNAI1
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 29 kDa
• Gene Name: snail family transcriptional repressor 1
• Database Link:
  Entrez Gene 6615 Human
  UniProt ID O95863
• Background: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.
• Synonyms: SNAH, Protein snail homolog 1