LKB1 (STK11) Mouse Monoclonal Antibody [Clone ID: 4H12]

CAT#: AM06552SU-N

LKB1 (STK11) mouse monoclonal antibody, clone 4H12, Ascites

Product Images

Western blot analysis using STK11 antibody Cat.-No AM06552SU-N against NIH/3T3 (1), Raw246.7 (2), COS7 (3), Jurkat (4), HEK293 (5) and A431 (6) cell lysate.

• 

  Flow Cytometric analysis of K562 cells using STK11 antibody Cat.-No AM06552SU-N (green) and negative control (purple).

Specifications

Product Data

• Clone Name: 4H12
• Applications: ELISA, FC, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
  Flow Cytometry: 1/200 - 1/400.
• Reactivities: Human, Monkey, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of Human STK11 expressed in E. Coli.
• Specificity: Recognizes STK11
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 54 kDa
• Gene Name: serine/threonine kinase 11
• Database Link:
  Entrez Gene 6794 Human
  UniProt ID Q15831
• Background: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.
• Synonyms: Serine/threonine-protein kinase 11, LKB1, PJS, NY-REN-19