PR3 (PRTN3) Mouse Monoclonal Antibody [Clone ID: 3B4]

CAT#: AM06358PU-N

PR3 (PRTN3) mouse monoclonal antibody, clone 3B4, Aff - Purified

Product Images

Western blot analysis using PRTN3 mouse mAb against PRTN3 (aa28-256)-hIgGFc transfected HEK293 cell lysate (1).

Specifications

Product Data

• Clone Name: 3B4
• Applications: ELISA, WB
• Recommended Dilution: Western Blot: 1/500 - 1/2000.
  ELISA: 1/10000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
• Specificity: This antibody reacts to Proteinase 3.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Stabilizer: 50% glycerol
  Preservative: 0.03% sodium azide
• Purification: Affinity chromatography on Protein G
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 28 kDa
• Gene Name: proteinase 3
• Database Link:
  Entrez Gene 5657 Human
  UniProt ID P24158
• Background: Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
• Synonyms: Myeloblastin, MBN, Leukocyte proteinase 3, Proteinase 3, PRTN3, PR-3, Neutrophil proteinase 4, NP-4, P29, Wegener autoantigen, AGP7