BNP (NPPB) Mouse Monoclonal Antibody [Clone ID: 9H6B4]

CAT#: AM06192SU-N

BNP (NPPB) mouse monoclonal antibody, clone 9H6B4, Ascites

Product Images

Immunohistochemical analysis of paraffin-embedded human normal myocardium, showing cytoplasmic localization using BNP2 antibody with DAB staining.

Specifications

Product Data

• Clone Name: 9H6B4
• Applications: ELISA, IHC
• Recommended Dilution: ELISA: /10000
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic peptide corresponding to amino acids (Gly-Leu-Gln-Glu-Gln-Arg-Asn-His-Leu-Gln-Gly-Lys-Leu-Cys) of human BNP, conjugated to KLH.
• Formulation: State: Ascites
  State: Ascitic fluid containing 0.03% Sodium Azide.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: natriuretic peptide B
• Database Link:
  Entrez Gene 4879 Human
  UniProt ID P16860
• Background: BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP and BNP act mainly as cardiac hormones, produced primarily by the atrium and ventricle, respectively, while the gene encoding C-type natriuretic peptide is expressed mainly in the brain. BNP circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. It is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic.
• Synonyms: NPPB, Brain natriuretic peptide, BNP, proBNP