alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 2B2D1]

CAT#: AM06128SU-N

alpha Synuclein (SNCA) mouse monoclonal antibody, clone 2B2D1, Ascites

Product Images

Western blot analysis using SNCA antibody Cat.-No AM06128SU-N against truncated SNCA recombinant protein.

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  Immunohistochemical analysis of paraffin-embedded human glioma tissue, showing membrane localization using SNCA antibody Cat.-No AM06128SU-N with DAB staining.

Specifications

Product Data

• Clone Name: 2B2D1
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000.
  Western Blot: 1/500 - 1/2000.
  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Purified recombinant fragment of SNCA expressed in E. Coli.
• Specificity: Recognizes Alpha-synuclein (SNCA).
• Formulation: State: Ascites
  State: Ascitic fluid
  Preservative: 0.03% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: synuclein alpha
• Database Link:
  Entrez Gene 6622 Human
  UniProt ID P37840
• Background: Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
• Synonyms: NACP, PARK1