alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: 4D6]

CAT#: AM05094PU-N

alpha Synuclein (SNCA) mouse monoclonal antibody, clone 4D6, Purified

Specifications

Product Data

• Clone Name: 4D6
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Western/Dot Blot: 1/100-1/10,000.
  Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Embedded Tissues: 1/100-1/1000 (No formic Acid, Enzyme or HIER required).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified E. coli produced Human Alpha-Synuclein.
• Specificity: This antibody recognizes Human Alpha-Synuclein. Other species not tested.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction from Tissue Culture Supernatant
  Preservative: None
• Concentration: lot specific
• Purification: Protein A Chromatography
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: synuclein alpha
• Database Link:
  Entrez Gene 6622 Human
  UniProt ID P37840
• Background: Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.
• Synonyms: NACP, PARK1