Properdin (CFP) Mouse Monoclonal Antibody [Clone ID: 10-18]

CAT#: AM01337PU-N

Properdin (CFP) mouse monoclonal antibody, clone 10-18, Purified

Specifications

Product Data

• Clone Name: 10-18
• Applications: ELISA, FN, IHC
• Recommended Dilution: ELISA.
  Functional Assays.
  Immunohistochemistry on frozen sections.
  Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Native purified factor P from human serum.
• Specificity: This antibody recognises human factor P, a 53 kDa glycosylated protein present in blood serum.
• Formulation: Borate buffered saline pH 8.2 containing 0.02% Sodium Azide
  State: Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: complement factor properdin
• Database Link:
  Entrez Gene 5199 Human
  UniProt ID P27918
• Background: Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.
• Synonyms: CFP, PFC, Complement factor P
• Note: This antibody is reported to inhibit the function of factor P. Removal of Sodium Azide is recommended prior to use in functional assays.

Reference Data

• Protein Families: Secreted Protein