Adenovirus (Hexon) Mouse Monoclonal Antibody [Clone ID: 7C11]
Adenovirus (Hexon) mouse monoclonal antibody, clone 7C11, Purified
Immunohistochemistry on frozen sections.
|Immunogen||Hexon antigen of human and canine adenoviruses (Type 1)|
|Specificity||Reacts to Adenovirus Hexon.|
|Formulation||PBS, pH 7,4 containing 0.09% Sodium Azide
State: Liquid purified Ig
|Purification||Affinity chromatography on Protein A|
|Storage||Store at the antibody undiluted at 2-8°C.
DO NOT FREEZE.
|Stability||Shelf life: one year from despatch.|
|Background||Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease.
Hexon protein is a major coat protein of adenoviruses. Adenoviruses capsids have three principal protein components: the hexon, the penton, and the fiber. Hexon consists of three subunits together forming two major components of different morphological symmetry. A triangular top with three towers of density is superimposed on a more bulky pseudo hexagonal base. The symmetry of the top is in accord with the trimeric nature of hexon, but that of the base derives from the molecular function, which is to provide a densely packed impenetrable protective outer layer for the virion.