Mouse Ifnar1 activation kit by CRISPRa

CAT#: GA202078

Ifnar1 CRISPRa kit - CRISPR gene activation of mouse interferon (alpha and beta) receptor 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Ifnar1
• Locus ID: 15975
• Kit Components:

  GA202078G1, Ifnar1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202078G2, Ifnar1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202078G3, Ifnar1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_010508
• UniProt ID: P33896
• Synonyms: CD118; Ifar; Ifnar; Ifrc; Infar
• Summary: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (By similarity). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).[UniProtKB/Swiss-Prot Function]