Human Tyrosine Hydroxylase (TH) activation kit by CRISPRa

CAT#: GA104861

TH CRISPRa kit - CRISPR gene activation of human tyrosine hydroxylase

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TH
• Locus ID: 7054
• Kit Components:

  GA104861G1, Tyrosine Hydroxylase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104861G2, Tyrosine Hydroxylase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104861G3, Tyrosine Hydroxylase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000360, NM_199292, NM_199293
• UniProt ID: P07101
• Synonyms: DYT5b; DYT14; TYH
• Summary: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]