KLHL25 (NM_022480) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC206979L2V

Lenti ORF particles, KLHL25 (mGFP-tagged) - Human kelch-like 25 (Drosophila) (KLHL25), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: KLHL25
• Synonyms: ENC-2; ENC2
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_022480
• ORF Size: 1767 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC206979).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_022480.3
• RefSeq Size: 3683 bp
• RefSeq ORF: 1770 bp
• Locus ID: 64410
• UniProt ID: Q9H0H3
• Cytogenetics: 15q25.3
• Domains: BTB, Kelch
• MW: 65.9 kDa
• Gene Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.[UniProtKB/Swiss-Prot Function]