CD117 Monoclonal Antibody [Clone ID: ACK4]
CAT#: TA363843
CD117 (c-kit, Receptor for Stem Cell Factor), rat anti mouse, clone ACK4
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Specifications
Product Data | |
Clone Name | ACK4 |
Applications | IHC |
Recommended Dilution | Tested for immunohistochemistry (IHC); has been described to work in FACS. Approximate working dilution for IHC: Frozen sections: 0.4µg/ml (1:1000) Paraffin sections: does not react on routinely processed paraffin sections. Suggested positive control: Mouse spleen and tongue |
Reactivities | Mouse |
Clonality | Monoclonal |
Immunogen | IL-3 dependent mast cells derived from WB+/+ mice. |
Specificity | Mouse: receptor for stem cell factor
Other species: not tested Epitope: The antigen is a 145kD membrane protein (reduced or unreduced) that belongs to the immunoglobulin supergene family. The epitope has not been characterized. Distribution: Isolated Cells: The antigen is described to be present on 5-10% of total adult bone marrow cells. Tissue Sections: The antigen is expressed on CD117 positive cells in various tissues e.g. in mouse spleen and tongue. There is a staining on cells in the red pulp of spleen, whereas there are only few cells with strong staining in tongue. |
Formulation | Affinity purified, lyophilized Reconstitute by adding 0.5ml distilled water. This stock solution contains 0.4mg/ml IgG, phosphate buffered saline pH 7.2 (PBS), 5mg/ml bovine serum albumin (BSA) as a stabilizer and 0.09% sodium azide as a preservative. |
Concentration | N/A |
Conjugation | Unconjugated |
Storage | Original vial: 1 year at 4° - 8°C. Stock solution or aliquots thereof: 1 year at -20°C. Avoid repeated thawing and freezing. |
Gene Name | kit oncogene |
Database Link | |
Background | Monoclonal antibody ACK4 recognizes the receptor for Stem Cell Factor (SCF) / Steel Factor. The cellular function of CD117 is that of a growth factor receptor. The ligand exists in both soluble and mambrane form. The interaction between SCF and c-kit is essential for the development of hematopoietic, gonadal and pigment stem cells. c-kit positive cells are a subset of CD34+ hematopoietic precursor cells, expression of CD117 can be found on 5-10% of total adult bone marrow cells. |
Synonyms | C-Kit; CD117; PBT; SCFR |
Reference Data |
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