KCNMB4 Mouse Monoclonal Antibody [Clone ID: S18A-3]

CAT#: TA326489

Mouse Monoclonal Anti-BKBeta4 Antibody

Product Images

IHC of BK Beta4 in brain tissues using a dilution of the antibody

Specifications

Product Data

• Clone Name: S18A-3
• Applications: IHC
• Recommended Dilution: WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 45-167 (entire extracellular domain) of mouse BKBeta4
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium calcium-activated channel subfamily M regulatory beta subunit 4
• Database Link:
  NP_055320
  Entrez Gene 58802 MouseEntrez Gene 66016 RatEntrez Gene 27345 Human
  UniProt ID Q86W47
• Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release . A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia . This has major implications on other physiological processes in tissues other than the brain.
• Synonyms: beta member 4; calcium-activated potassium channel beta 4 subunit; large conductance calcium-dependent potassium ion channel beta 4 subunit; potassium large conductance calcium-activated channel; subfamily M
• Note: Detects ~24kDa.

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction