PCDHB16 Rabbit Polyclonal Antibody

CAT#: TA322247

Anti-PCDHB16 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human brain tissue using TA322247 (PCDHB16 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human brain tissue using TA322247 (PCDHB16 Antibody) at dilution 1/30, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human brain
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 29-300 amino acids of human protocadherin beta 16
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protocadherin beta 16
• Database Link:
  NP_066008
  Entrez Gene 57717 Human
  UniProt ID Q9NRJ7
• Background: This gene is a member of the protocadherin beta gene cluster; one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes; each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters; the transcripts from these genes are made up of only one large exon; not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
• Synonyms: ME1; PCDH-BETA16; PCDH3X; PCDHB8a

Reference Data

• Protein Families: Druggable Genome, Transmembrane