SIT (SIT1) Mouse Monoclonal Antibody [Clone ID: SIT-01]

CAT#: SM3074R

SIT (SIT1) mouse monoclonal antibody, clone SIT-01, PE

Product Images

Intracellular staining of human peripheral blood using anti-SIT (clone SIT-01) PE.

Specifications

Product Data

• Clone Name: SIT-01
• Applications: FC
• Recommended Dilution: Flow cytometry (1/50, intracellular staining).
  
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Bacterially produced recombinant intracellular fragment of human SIT
• Specificity: The antibody reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
  Label: PE
  State: Liquid purified Ig fraction
  Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Concentration: lot specific
• Conjugation: PE
• Storage: Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: signaling threshold regulating transmembrane adaptor 1
• Database Link:
  Entrez Gene 27240 Human
  UniProt ID Q9Y3P8
• Background: SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
• Synonyms: gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SIT

Reference Data

• Protein Families: Transmembrane