BCL2 Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | ELISA |
Recommended Dilution | ELISA: React with the synthetic Bcl-2 peptide coated on ELISA plate. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide derived from human Bcl-2, conjugated with KLH |
Specificity | This antibody recognizes the synthetic Bcl-2 peptide. |
Formulation | 0.01M PBS, pH 7.4 State: Azide Free State: Lyophilized Ig fraction |
Reconstitution Method | Restore with Double distilled water to adjust the final concentration to 1.00 mg/ml. |
Purification | Protein G affinity purified |
Conjugation | Unconjugated |
Storage | Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | B-cell CLL/lymphoma 2 |
Database Link | |
Background | Bcl2 is a 25kDa inner mitochondrial membrane protein with anti-apoptotic function. It is believed that Bcl-2 suppresses apoptosis by inhibiting mitochondrial cytochrome C release, blocking caspase cascade and regulating mitochondrial calcium homeostasis. Bcl- 2 is identified from the study of B-cell lymphoma. About 90% of follicular lymphoma is caused by Bcl-2 overexpression resulted from the translocation of Bcl-2 gene from chromosome 18 to the immunoglobulin heavy chain enhancer on chromosome 14. Bcl-2 is also involved with other malignancies such as melanoma, breast cancer, prostate cancer and lung cancer. |
Synonyms | BCL2, Bcl-2 alpha |
Reference Data |
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