Artemis (DCLRE1C) Goat Polyclonal Antibody

CAT#: AP07832PU-N

Artemis (DCLRE1C) goat polyclonal antibody, Aff - Purified

Product Images

Figure 1. Staining Artemis in Lymph node by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/10000 - 1/20000.
  Immunohistochemistry on Paraffin Sections: 1.25 - 2.5 µg/ml.
  Western Blot: 1/500 - 1/2000.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic Peptide corresponding to aa 482-495 of Human ARTEMIS (DCLRE1C DNA cross-link repair 1C).
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody (in aliquots) at -20°C.
  Dilute only prior to immediate use.
  Avoid cycles of freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Gene Name: DNA cross-link repair 1C
• Database Link:
  Entrez Gene 64421 Human
  UniProt ID Q96SD1
• Background: Human Artemis is a newly identified 78.4 kDa, novel DNA double-strand break repair/v(d)j recombination protein. This gene is located at human chromosome 10. Artemis has a role in T and B lymphocyte immunodeficiency and in predisposition to lymphoma through the NHEJ pathway of DNA repair. DNA-PKcs regulates Artemis by both phosphorylation and complex formation to permit enzymatic activities that are critical for the hairpin-opening step of V(D)J recombination and for the 5' and 3' overhang processing in non-homologous DNA end joining.
• Synonyms: DCLRE1C, ASCID, SCIDA, SNM1C, SNM1-like protein, A-SCID protein