Kappa Opioid Receptor (OPRK1) Rabbit Polyclonal Antibody

CAT#: AP01330PU-N

Kappa Opioid Receptor (OPRK1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Kappa Opioid Receptor antibody in extracts from COS-7 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human KOR-1.
• Specificity: This antibody detects endogenous levels of KOR-1 protein (region surrounding Arg361).
• Formulation: PBS, pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~42 kDa
• Gene Name: opioid receptor kappa 1
• Database Link:
  Entrez Gene 4986 Human
  UniProt ID P41145
• Background: Opioid is the term used to designate a group of compounds that are opium-like in their properties. These drugs have effects on perception of pain, consciousness, motor control, mood, and autonomic function, and can induce physical dependence. Pharmacological studies suggested that there are at least 3 major classes of opioid receptors, designated delta, kappa, and mu. They differ in their affinity for various opioid ligands and in their cellular distribution. Studies of the receptors in the mouse and rat show that they are structurally related and are members of the family of 7 transmembrane-spanning G protein-coupled receptors. The kappa opiod receptor inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. It is the receptor for beta-endorphin.
• Synonyms: OPRK1, OPRK, KOR1, KOR-1