Adenosine Receptor A2a (ADORA2A) Rabbit Polyclonal Antibody

CAT#: AP01259PU-N

Adenosine Receptor A2a (ADORA2A) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Adenosine A2A-R Antibody in extracts from HepG2 cells.

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  Immunohistochemistry analysis of Adenosine A2A-R Antibody in paraffin-embedded human skeleta l muscle tissue.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 330-380 of Human ADORA2A.
• Specificity: This antibody detects endogenous levels of Adenosine A2A-R protein. (region surrounding Tyr361)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~45 kDa
• Gene Name: adenosine A2a receptor
• Database Link:
  Entrez Gene 135 Human
  UniProt ID P29274
• Background: Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response and the inhibition of protein synthesis. The adenosine receptors, including Adenosine A1-R, Adenosine A2A-R, Adenosine A2B-R and Adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthasis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNFα and blocks the endotoxin CD14 receptor signal transduction pathway.
• Synonyms: ADORA2A, ADORA2