c-Myb (MYB) Mouse Monoclonal Antibody [Clone ID: MYB286]
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Specifications
Product Data | |
Clone Name | MYB286 |
Applications | FC, IF, IP, WB |
Recommended Dilution | ELISA: Use BSA free Antibody for coating. Flow Cytometry: 0.5-1 μg/million cells. Immunofluorescence: 1-2 μg/ml. Western Blotting: 0.5-1 μg/ml. Immunoprecipitation: 1-2 μg/500 μg protein lysate. Positive Control: Jurkat, MOLT-4, COLO or BT-20 cells. Colon or breast carcinomas. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | A synthetic peptide, corresponding to aa 119-135 (RRKVEQEGYPQESSKAG) of c-Myb oncoprotein, coupled to KLH. |
Specificity | Recognizes c-Myb Oncoprotein. Cellular Localization: Nuclear. |
Formulation | 10mM PBS State: Purified State: Liquid purified IgG fraction from Bioreactor Concentrate Stabilizer: 0.05% BSA Preservative: 0.05% Sodium Azide |
Concentration | lot specific |
Purification | Protein A/G Chromatography |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~75 kDa |
Gene Name | MYB proto-oncogene, transcription factor |
Database Link | |
Background | The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-ter- minal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed prefere ntially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate. |
Synonyms | c-Myb |
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