PR3 (PRTN3) Mouse Monoclonal Antibody [Clone ID: 3B4]
Other products for "PRTN3"
Specifications
Product Data | |
Clone Name | 3B4 |
Applications | ELISA, WB |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Purified recombinant fragment of human Proteinase 3 expressed in E. Coli. |
Specificity | This antibody reacts to Proteinase 3. |
Formulation | PBS State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 50% glycerol Preservative: 0.03% sodium azide |
Purification | Affinity chromatography on Protein G |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 28 kDa |
Gene Name | proteinase 3 |
Database Link | |
Background | Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis. |
Synonyms | Myeloblastin, MBN, Leukocyte proteinase 3, Proteinase 3, PRTN3, PR-3, Neutrophil proteinase 4, NP-4, P29, Wegener autoantigen, AGP7 |
Reference Data |
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