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Home Recombinant Human Proteins All VEGFA Proteins

VEGFA (NM_001025366) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP780001 Recombinant protein of human Vascular endothelial growth factor A (VEGF) produced in Pichia Pastoris., 50 ug (Larger pack size?) $399 In Stock
TA500042 VEGFA (VEGF) mouse monoclonal antibody, clone OTI4G3 (formerly 4G3) $379 In Stock
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OriGene Data
Species:Human Expression Host:Pichia Pastoris
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC229662. Encoding the region (Ala27-Arg191) of human VEGFA
Tag:Tag-free Predicted MW:19.2 kDa
Purity:>95% as determined by SDS-PAGE and Coomassie blue staining
Concentration:Resuspend the protein to the desired concentration in proper buffer.
Buffer:Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.2
Endotoxin: <0.1 EU per 1 µg of the protein by the LAL
BioActivity: Measured in a cell proliferation assay using HUVEC Cells. The ED50 for this effect is typically 1.1 - 1.6 ng/ml.
Protein Families: Secreted ProteinDruggable Genome
Protein Pathways: Cytokine-cytokine receptor interactionmTOR signaling pathwayVEGF signaling pathwayFocal adhesionPathways in cancerRenal cell carcinomaMore Pathways >>
Protein Data
Protein Image

Reference Data
RefSeq: NP_001020537 RefSeq Size: 3665 RefSeq ORF: 1239
LocusID: 7422 Cytogenetic: 6p12  
Synonyms : MVCD1; VEGF; VPF
Summary: This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich


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