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Home Recombinant Human Proteins All RET Proteins

RET (NM_020975) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP710180 Recombinant protein of human ret proto-oncogene (RET), transcript variant 2, residues 29-635aa, with C-terminal DDK tag, expressed in sf9, 20ug, 20ug (Larger pack size?) 399 In Stock
TA307815 Rabbit monoclonal antibody against Ret(clone EPR2871) $325 In Stock
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OriGene Data
Species:Human Expression Host:Sf9 cells
Expression cDNA Clone or AA Sequence
A DNA sequence from TrueORF clone, RC214268, encoding the region(Met-Leu29-Arg635) of Homo sapiens RET
Tag:C-terminal DDK Predicted MW:67.78 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: EndocytosisPathways in cancerThyroid cancer
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_066124 RefSeq Size: 4757 RefSeq ORF: 3345
LocusID: 5979 Cytogenetic: 10q11.2  
Synonyms : CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET-ELE1; RET51
Summary: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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