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Home Recombinant Human Proteins All IL12B Proteins

IL12B (NM_002187) Purified Human Protein

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Cat. No. Description Datasheet Price Availability*  
TP309679 Recombinant protein of human interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), 20 ug (Larger pack size?) $680 In Stock
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC209679. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:34.6 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: Secreted ProteinTransmembraneDruggable Genome
Protein Pathways: Cytokine-cytokine receptor interactionToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayJak-STAT signaling pathwayType I diabetes mellitusAllograft rejectionMore Pathways >>
Protein Data
Protein Image

Reference Data
RefSeq: NP_002178 RefSeq Size: 2347 RefSeq ORF: 987
LocusID: 3593 Cytogenetic: 5q31.1-q33.1  
Synonyms : CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2; IL-12; IL12
Summary: This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich


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