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Home Recombinant Human Proteins All BCL2L1 Proteins

BCL2L1 (NM_138578) Purified Human Protein

Specifications Citations Customer Service Product Documents
Cat. No. Description Datasheet Price Availability*  
TP301314 Recombinant protein of human BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 1, 20 µg (Larger pack size?) 680 In Stock
TA500097 anti-Bcl-XL mouse monoclonal antibody,clone 4A9 $379 In Stock
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Also for BCL2L1 (NM_138578)
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OriGene Data
Species:Human Expression Host:HEK293 cells
Expression cDNA Clone or AA Sequence
Recombinant protein was produced with TrueORF clone, RC201314. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag:C-terminal MYC/DDK Predicted MW:25.9 kDa
Purity:> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration:>50 ug/mL as determined by microplate BCA method
Buffer:25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families: ES Cell Differentiation/IPSTransmembraneDruggable Genome
Protein Pathways: ApoptosisJak-STAT signaling pathwayAmyotrophic lateral sclerosis (ALS)Pathways in cancerPancreatic cancerChronic myeloid leukemiaMore Pathways >>
Protein Data
Protein Image
 

Reference Data
RefSeq: NP_612815 RefSeq Size: 2575 RefSeq ORF: 702
LocusID: 598 Cytogenetic: 20q11.21  
Synonyms : Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52
Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].
*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information
**: DDK-tag is the same as FLAG tag. Flag® is a registered trademark of Sigma-Aldrich

 

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