p53 (wild type) Tumor Suppressor Protein and Transcription Factor, 5,000 units

Cat. No.   Description TP200114 P2001-01 p53 (wild type) Tumor Suppressor Protein and Transcription Factor, 5,000 units The associated gene in an expression vector NM_000546 is also available.

Description:

p53 was identified as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, this protein is a transcription factor capable of regulating the expression of a subset of downstream genes (1-5). Different mutations in p53 gene have been characterized in a variety of human cancers (6, 7). Loss or mutation of p53 function is highly correlated with tumorigenesis.