OriGene - PSENEN (NM_172341) Human ORF cDNA Clone

Western Blot Validated

The same insert cloned in Lenti and other vectors is also available.

Cat. No.	Description	Vector	Price	Availability
RC203272L1	Lenti ORF clone of Human presenilin enhancer 2 homolog (C. elegans) (PSENEN) , Myc-DDK-tagged	pLenti-C-Myc-DDK pLenti-C-mGFP pCMV6-AC-GFP	$750	2 Weeks
TR30022	Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns)		$360	In Stock

TrueORF Data for RC203272

Vector:	pCMV6-Entry Change vector?	Tag: C-terminal Myc-DDK	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 306 bp Predicted Protein MW: 11.8 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Transmembrane Druggable Genome
Protein Pathways:	Notch signaling pathway Alzheimer's disease

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_172341.1, NP_758844	RefSeq Size: 678	RefSeq ORF: 306
Synonyms : MDS033; MSTP064; PEN-2; PEN2
LocusID: 55851	Cytogenetic: 19q13.12
Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

PSENEN Mouse Clones

SKU	Description	Amount	Price	Shipping
MC202131	Mus musculus presenilin enhancer 2 homolog (C. elegans) (Psenen) as transfection-ready DNA	10 ug	$165	Next day
MR200307	Myc-DDK-tagged ORF clone of Mus musculus presenilin enhancer 2 homolog (C. elegans) (Psenen) as transfection-ready DNA	10 ug	$380	Next day
MG200307	GFP-tagged ORF clone of Mus musculus presenilin enhancer 2 homolog (C. elegans) (Psenen) in a GFP expression vector	10 ug	$420	3 weeks

PSENEN Rat Clones

SKU	Description	Amount	Price	Shipping
RN210155	NativeORF clone of Rattus norvegicus presenilin enhancer 2 homolog (C. elegans) (Psenen) as transfection-ready DNA	10 ug	$380	2 weeks
RR210155	Myc-DDK-tagged ORF clone of Rattus norvegicus presenilin enhancer 2 homolog (C. elegans) (Psenen) as transfection-ready DNA	10 ug	$380	2 weeks

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Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

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PSENEN (NM_172341) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

PSENEN Mouse Clones

PSENEN Rat Clones

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