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Home cDNA Clone TrueORF All DDR1 ORF Clones

DDR1 (NM_013993) Human cDNA ORF Clone

Specifications Citations (0) Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC600061 DDR1 (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens discoidin domain receptor tyrosine kinase 1, transcript variant 2, Signal peptide (1-18) plus EC domain (21-417), 10µg
480
In Stock
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification
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TrueORF Data for RC600061
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Vector: pCMV6-XL5-DDK-His   Change vector? Tag: C-terminal DDK-His
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1245 bp
Predicted Protein MW: 46.2 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map
OTI Annotation: This clone was engineered to express the extra cellular domain of the protein with an expression tag
OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Protein KinaseTransmembraneDruggable Genome

Reference Data
RefSeq: NM_013993.2, NP_054699
RefSeq Size: 3877 RefSeq ORF: 2742
Synonyms : CAK; CD167; DDR; EDDR1; HGK2; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
LocusID: 780 Cytogenetic: 6p21.3 Domains: FA58C, pkinase, TyrKc, S_TKc
Summary: Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].

 

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