OriGene - GSK3B (NM_001146156) Human ORF cDNA Clone

Western Blot Validated

The same insert cloned in a GFP-tagging vector is also available

Cat. No.	Description	Vector	Price	Availability
RG228888	GFP-tagged ORF clone of Homo sapiens glycogen synthase kinase 3 beta (GSK3B), transcript variant 2 as transfection-ready DNA	pCMV6-AC-GFP	$590	3 Weeks
TA150041	2H8, Anti-tGFP monoclonal antibody, 100µl		$248	In Stock

TrueORF Data for RC228888

Vector:	pCMV6-Entry Change vector?	Tag: C-terminal Myc-DDK	Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Sequence Data:	ORF Nucleotide Sequence CHROMATOGRAMS Protein Sequence	ORF Size: 1263 bp Predicted Protein MW: 46.6 kDa
Restriction Sites:	SgfI-MluI Cloning Scheme for this gene Plasmid Map
OTI Annotation:	This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer:	Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
Product Components:	The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families:	Protein Kinase Druggable Genome
Protein Pathways:	ErbB signaling pathway Chemokine signaling pathway Cell cycle Wnt signaling pathway Hedgehog signaling pathway Axon guidance More Pathways >>

* The lysates used for this WB picture contain the overexpressed empty vector or the Myc-DDK tagged ORF clone.

Reference Data

RefSeq: NM_001146156.1, NP_001139628	RefSeq Size:	RefSeq ORF: 1263
Synonyms : GSK3beta isoform; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta
LocusID: 2932	Cytogenetic: 3q13.3
Summary: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].

ORF Clones Citations:

Solute Carrier 11A1 Is Expressed by Innate Lymphocytes and Augments Their Activation, Jodi F. Hedges, Emily Kimmel, Deann T. Snyder, Maria Jerome, and Mark A. Jutila, J. Immunol., Apr 2013; 190: 4263 - 4273. [SLC11A1]

A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function, Feng Gao, Hansel E. Ihn, Marisa W. Medina, and Ronald M. Krauss, Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [LDLR]

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Lisa Muniz, Sylvain Egloff, and Tamás Kiss, Nucleic Acids Res., Apr 2013; 41: 4686 - 4698. [MEPCE ]

Structural basis for angiopoietin-1–mediated signaling initiation, Xuehong Yu, Tom C. M. Seegar, Annamarie C. Dalton, Dorothea Tzvetkova-Robev, Yehuda Goldgur, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov, and William A. Barton, PNAS, Apr 2013; 110: 7205 - 7210. [ANGPT1]

Inverted Formin 2 Regulates Actin Dynamics by Antagonizing Rho/Diaphanous-related Formin Signaling, Hua Sun, Johannes Schlondorff, Henry N. Higgs, and Martin R. Pollak, J. Am. Soc. Nephrol., Apr 2013; 10.1681/ASN.2012080834. [INF2]

MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway, Chutima Kumkhaek, Wulin Aerbajinai, Wenli Liu, Jianqiong Zhu, Naoya Uchida, Roger Kurlander, Matthew M. Hsieh, John F. Tisdale, and Griffin P. Rodgers, Blood, Apr 2013; 121: 3216 - 3227. [MFHAS1 ]

Proximal tubule-dominant transfer of AT1a receptors induces blood pressure responses to intracellular angiotensin II in AT1a receptor-deficient mice, Xiao C. Li and Jia L. Zhuo, Am J Physiol Regulatory Integrative Comp Physiol, Apr 2013; 304: R588 - R598. [AGTR1A ]

DCNL1 Functions as a Substrate Sensor and Activator of Cullin 2-RING Ligase, Pardeep Heir, Roxana I. Sufan, Samantha N. Greer, Betty P. Poon, Jeffrey E. Lee, and Michael Ohh, Mol. Cell. Biol., Apr 2013; 33: 1621 - 1631. [DCNL1]

More TrueClone Citations >>

GSK3B Mouse Clones

SKU	Description	Amount	Price	Shipping
MC207532	Mus musculus glycogen synthase kinase 3 beta (Gsk3b) as transfection-ready DNA	10 ug	$380	Next day
MR206669	Myc-DDK-tagged ORF clone of Mus musculus glycogen synthase kinase 3 beta (Gsk3b) as transfection-ready DNA	10 ug	$380	Next day
MG206669	GFP-tagged ORF clone of Mus musculus glycogen synthase kinase 3 beta (Gsk3b) in a GFP expression vector	10 ug	$420	3 weeks

GSK3B Rat Clones

SKU	Description	Amount	Price	Shipping
RN206573	NativeORF clone of Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b) as transfection-ready DNA	10 ug	$380	3 weeks
RR206573	Myc-DDK-tagged ORF clone of Rattus norvegicus glycogen synthase kinase 3 beta (Gsk3b) as transfection-ready DNA	10 ug	$380	3 weeks

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Use Blue Heron gene synthesis and make clone in any of OriGene's expression vectors.

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GSK3B (NM_001146156) Human cDNA ORF Clone

Western Blot Validated

ORF Clones Citations:

GSK3B Mouse Clones

GSK3B Rat Clones

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