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Home cDNA Clone TrueORF All PRF1 ORF Clones

PRF1 (NM_001083116) Human cDNA ORF Clone

Western Blot Validated

Specifications Citations Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC208940 PRF1 (Myc-DDK-tagged)-Human perforin 1 (pore forming protein) (PRF1), transcript variant 2, 10µg
$660
3-4 weeks
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification

The same insert cloned in Lenti and other vectors is also available.

Cat. No. Description Vector Price Availability  
RC208940L2 Lenti-ORF clone of PRF1 (mGFP-tagged)-Human perforin 1 (pore forming protein) (PRF1), transcript variant 2, (10ug)

1130 6 Weeks
TR30022 Lenti-vpak packaging kit - packaging plasmids and transfection reagent (10 rxns) Lenti-vpak-app-guide $390 In Stock
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Also for PRF1 (NM_001083116)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody
TrueORF Data for RC208940
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Vector: pCMV6-Entry   Change vector? Tag: C-terminal Myc-DDK
Western validation with an anti-DDK antibody *
L: Control HEK293 lysate
R: Over-expression lysate
Lysate_Image
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 1668 bp
Predicted Protein MW: 59.1 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map Plasmid Map
OTI Annotation: This clone was engineered to express the complete ORF with an expression tag.
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Druggable Genome
Protein Pathways: Natural killer cell mediated cytotoxicityType I diabetes mellitusAutoimmune thyroid diseaseAllograft rejectionGraft-versus-host diseaseViral myocarditis

Reference Data
RefSeq: NM_001083116.1, NP_001076585
RefSeq Size: 2555 RefSeq ORF: 1668
Synonyms : FLH2; HPLH2; P1; PFN1; PFP
LocusID: 5551 Cytogenetic: 10q22
Summary: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].

 

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