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Home cDNA Clone TrueORF All INSR ORF Clones

INSR (NM_000208) Human cDNA ORF Clone

Specifications Citations (0) Clones of Other Species Product Documents
Cat. No. Description Price Availability  
RC600010 INSR (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens insulin receptor, transcript variant 1, Signal peptide (1-27) plus EC domain (763-956), 10µg
$380
In Stock
TA50011-100 4C5, Anti-DDK monoclonal antibody, 100µl $248 In Stock
Clone Modification
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TrueORF Data for RC600010
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Vector: pCMV6-XL5-DDK-His   Change vector? Tag: C-terminal DDK-His
Sequence Data: ORF Nucleotide Sequence
Protein Sequence
ORF Size: 663 bp
Predicted Protein MW: 24.5 kDa
Restriction Sites: SgfI-MluI     Cloning Scheme for this gene     Plasmid Map
OTI Annotation: This clone was engineered to express the extra cellular domain of the protein with an expression tag
OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components: The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
Protein Families: Protein KinaseTransmembraneDruggable Genome
Protein Pathways: Adherens junctionInsulin signaling pathwayType II diabetes mellitus

Reference Data
RefSeq: NM_000208.2, NP_000199
RefSeq Size: 9059 RefSeq ORF: 4149
Synonyms : CD220; HHF5
LocusID: 3643 Cytogenetic: 19p13.3-p13.2
Summary: After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

 

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