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HomeAll Cancer Mutant ClonesWT1 Mutants

Description of the mutations of WT1 (NM_024426) Mutants

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

 

SKUMutation DescriptionAffected Codon#Affected NT#DescriptionEffect
RC403435 S118X118353C>AWilms tumour
RC403436 Q142X142424C>TWilms tumour
RC403437 Y177X177531C>AWilms tumour
RC403438 A199T199595G>AHypospadias
RC403439 S233X233698C>AWilms tumour
RC403440 P249S249745C>TWilms tumour
RC403441 Q253X253757C>TWilms tumour
RC403442 Y289X289867C>GDenys-Drash syndrome
RC403443 S291N291872G>AWilms tumour
RC403444 W306X306917G>AWilms tumour
RC403445 G321A321962G>CWilms tumour
RC403446 Y339X3391017C>GWilms tumour
RC403447 C350X3501050C>AWilms tumour
RC403448 R363X3631087A>TWilms tumour
RC403449 R369X3691105C>TWilms tumour
RC403450 R380Q3801139G>ADiffuse mesangial sclerosis
RC403451 S381X3811142C>AWilms tumour
RC403452 P390T3901168C>AWilms tumour
RC403453 C398Y3981193G>ADenys-Drash syndrome
RC403454 L408X4081223T>GWilms tumour
RC403455 Q409X4091225C>TWilms tumour
RC403456 M410R4101229T>GDenys-Drash syndrome
RC403457 C423Y4231268G>ADenys-Drash syndrome
RC403458 C423G4231267T>GWilms tumour
RC403459 C428Y4281283G>ADenys-Drash syndrome
RC403460 C428G4281282T>GDenys-Drash syndrome
RC403461 R430X4301288C>TDenys-Drash syndrome
RC403462 F432L4321294T>CNephrotic syndrome
RC403463 R434H4341301G>ADenys-Drash syndrome
RC403464 R434L4341301G>TDenys-Drash syndrome
RC403465 R434C4341300C>TDenys-Drash syndrome
RC403466 Q437H4371311G>TDenys-Drash syndrome
RC403467 Q437P4371310A>CDenys-Drash syndrome
RC403468 Q437X4371309C>TWilms tumour
RC403469 H441Q4411323C>GDenys-Drash syndrome
RC403470 H441Y4411321C>TDenys-Drash syndrome
RC403471 H445R4451334A>GDenys-Drash syndrome
RC403472 H445Y4451333C>TDenys-Drash syndrome
RC403473 G447C4471339G>TNephrotic syndrome
RC403474 P450S4501348C>TNephrotic syndrome?
RC403475 F451L4511351T>CDiffuse mesangial sclerosis
RC403476 C453R4531357T>CDenys-Drash syndrome
RC403477 C456F4561367G>TDenys-Drash syndrome
RC403478 C456Y4561367G>ADenys-Drash syndrome
RC403479 C456R4561366T>CNephrotic syndrome
RC403480 Q457X4571369C>TRenal dysfunction & renal blastema
RC403481 R458X4581372C>TWilms tumour
RC403482 F460L4601380C>GFocal segmental glomerulosclerosis
RC403483 F460L4601378T>CFrasier syndrome
RC403484 R462L4621385G>TWilms tumour
RC403485 R462P4621385G>CDenys-Drash syndrome
RC403486 R462Q4621385G>ADenys-Drash syndrome
RC403487 R462W4621384C>TDenys-Drash syndrome
RC403488 D464G4641391A>GDenys-Drash syndrome
RC403489 D464Y4641390G>TDenys-Drash syndrome
RC403490 D464N4641390G>ADenys-Drash syndrome
RC403491 H465P4651394A>CNephrotic syndrome
RC403492 L466P4661397T>CDenys-Drash syndrome
RC403493 H469R4691406A>GNephrotic syndrome
RC403494 H469Y4691405C>TDenys-Drash syndrome
RC403495 H473R4731418A>GDenys-Drash syndrome
RC403496 X518W5181554A>GWilms tumour

 

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