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HomeAll Cancer Mutant ClonesSTK11 Mutants

Description of the mutations of STK11 (NM_000455) Mutants

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

 

SKUMutation DescriptionAffected Codon#Affected NT#DescriptionEffect
RC400276 Y60fs*160c.180delCFrameshift
RC400268 D194N194c.580G>AMissense
RC400269 D194Y194c.580G>TMissense
RC400270 P279fs*6279c.837delCFrameshift
RC400271 G171S171c.511G>AMissense
RC400272 F354L354c.1062C>GMissense
RC400273 P281L281c.842C>TMissense
RC400274 P281fs*6281c.842delCFrameshift
RC400275 V66M66c.196G>AMissense
RC400277 R304W304c.910C>TMissense
RC400278 T32T32c.96C>GMissense
RC400279 F263fs*22263c.787_790delTTGTFrameshift
RC400280 E57fs*757c.169delGFrameshift
RC400281 Y272Y272c.816C>TMissense
RC400282 Q170*170c.508C>TTruncation
RC400283 Q37*37c.109C>TTruncation
RC400284 W332*332c.996G>ATruncation
RC402189 K44X44130A>TGonadotrophin-independent precocious puberty
RC402190 Y49X49147C>APeutz-Jeghers syndrome
RC402191 E57X57169G>TPeutz-Jeghers syndrome
RC402192 Y60X60180C>GPeutz-Jeghers syndrome
RC402193 Y60X60180C>APeutz-Jeghers syndrome
RC402194 L67R67200T>GPeutz-Jeghers syndrome
RC402195 L67P67200T>CPeutz-Jeghers syndrome
RC402196 E70X70208G>TPeutz-Jeghers syndrome
RC402197 K81X81241A>TPeutz-Jeghers syndrome
RC402198 K84X84250A>TPeutz-Jeghers syndrome
RC402199 R86X86256C>TPeutz-Jeghers syndrome
RC402200 Q100X100298C>TPeutz-Jeghers syndrome
RC402201 K108R108323A>GPeutz-Jeghers syndrome
RC402202 Q112X112334C>TPeutz-Jeghers syndrome
RC402203 Y118X118354C>APeutz-Jeghers syndrome
RC402204 Y118X118354C>GPeutz-Jeghers syndrome
RC402205 Q123X123367C>TPeutz-Jeghers syndrome
RC402206 Y126X126378T>GPeutz-Jeghers syndrome
RC402207 E130X130388G>TPeutz-Jeghers syndrome
RC402208 C132X132396C>APeutz-Jeghers syndrome
RC402209 M136R136407T>GPeutz-Jeghers syndrome
RC402210 Q137X137409C>TPeutz-Jeghers syndrome
RC402211 E138X138412G>TPeutz-Jeghers syndrome
RC402212 Q152X152454C>TPeutz-Jeghers syndrome
RC402213 Y156X156468C>GPeutz-Jeghers syndrome
RC402214 F157S157470T>CPeutz-Jeghers syndrome
RC402215 D162N162484G>APeutz-Jeghers syndrome
RC402216 G163D163488G>APeutz-Jeghers syndrome
RC402217 L164M164490C>APeutz-Jeghers syndrome
RC402218 E165X165493G>TPeutz-Jeghers syndrome
RC402219 L167R167500T>GPeutz-Jeghers syndrome
RC402220 Q170P170509A>CPeutz-Jeghers syndrome
RC402221 H174R174521A>GPeutz-Jeghers syndrome
RC402222 D176N176526G>APeutz-Jeghers syndrome
RC402223 I177N177530T>APeutz-Jeghers syndrome
RC402224 N181T181542A>CPeutz-Jeghers syndrome
RC402225 N181Y181541A>TPeutz-Jeghers syndrome
RC402226 L182P182545T>CPeutz-Jeghers syndrome
RC402227 L184P184551T>CPeutz-Jeghers syndrome ?
RC402228 Q214X214640C>TPeutz-Jeghers syndrome
RC402229 Q220X220658C>TPeutz-Jeghers syndrome
RC402230 T230P230688A>CPeutz-Jeghers syndrome
RC402231 S232P232694T>CPeutz-Jeghers syndrome
RC402232 I238F238712A>TPeutz-Jeghers syndrome ?
RC402233 W239C239717G>CPeutz-Jeghers syndrome ?
RC402234 S240X240719C>APeutz-Jeghers syndrome
RC402235 G242E242725G>APeutz-Jeghers syndrome
RC402236 G242v242725G>TPeutz-Jeghers syndrome ?
RC402237 G242W242724G>TPeutz-Jeghers syndrome
RC402238 L245R245734T>GPeutz-Jeghers syndrome
RC402239 Y246X246738C>GPeutz-Jeghers syndrome
RC402240 G251S251751G>APeutz-Jeghers syndrome
RC402241 Y253X253759C>APeutz-Jeghers syndrome
RC402242 E256A256767A>CPeutz-Jeghers syndrome
RC402243 E256X256766G>TPeutz-Jeghers syndrome
RC402244 L285P285854T>CPeutz-Jeghers syndrome
RC402245 K287T287860A>CPeutz-Jeghers syndrome ?
RC402246 R297S297891G>TPeutz-Jeghers syndrome
RC402247 R297K297890G>APeutz-Jeghers syndrome
RC402248 R304P304911G>CPeutz-Jeghers syndrome
RC402249 H306Y306916C>TPeutz-Jeghers syndrome
RC402250 W308C308924G>TPeutz-Jeghers syndrome
RC402251 W308X308923G>APeutz-Jeghers syndrome
RC402252 P324L324971C>TPeutz-Jeghers syndrome
RC402253 K416X4161246A>TPeutz-Jeghers syndrome

 

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