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Description of the mutations of NRAS (NM_002524) Mutants

Reference:

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
Proc. Natl. Acad. Sci. U.S.A. 1985; 82:879-882

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion

R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

SKU	Mutation Description	Affected Codon#	Affected NT#	Description	Effect	Affected Protein Domain
RC400137	G12D	12	c.35	G>A/C	missense	GTP binding
RC400138	G12S	12	c.34	G>A	missense	GTP binding
RC400139	G12C	12	c.34	G>T	missense	GTP binding
RC400140	G12V	12	c.35	G>T	missense	GTP binding
RC400141	G12A	12	c.35	G>C	missense	GTP binding
RC400142	Q61P	61	c.182	A>C	missense	GTP binding
RC400143	Q61H	61	c.183	A>T	missense	GTP binding
RC400144	Q61L	61	c.182	A>T	missense	GTP binding
RC400145	Q61R	61	c.182	A>G	missense	GTP binding
RC400146	Q61K	61	c.181	C>A	missense	GTP binding
RC400147	G13C	13	c.37	G>T	missense	GTP binding
RC400148	G13R	13	c.37	G>C	missense	GTP binding
RC400149	A18T	18	c.52	G>A	missense	GTP binding
RC400150	G13D	13	c.38	G>A	missense	GTP binding
RC400151	G13V	13	c.38	G>T	missense	GTP binding
RC400152	G13A	13	c.38	A>C	missense	GTP binding
RC400153	G13S	13	c.37	G>A	missense	GTP binding

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Description of the mutations of NRAS (NM_002524) Mutants