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HomeAll Cancer Mutant ClonesEGFR Mutants

Description of the mutations of EGFR (NM_005228) Mutants

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

 

SKUMutation DescriptionAffected Codon#Affected NT#DescriptionEffect
RC400285 E709K709c.2125G>AMissense
RC400286 S768I768c.2303G>TMissense
RC400287 L747_S752del747c.2239_2256del18deletion
RC400288 L861Q861c.2582T>AMissense
RC400289 T790M790c.2369C>TMissense
RC400290 L858R858c.2573T>GMissense
RC400291 L858M858c.2572C>AMissense
RC400292 G729E729c.2186G>AMissense
RC400293 R108K108c.323G>AMissense
RC400294 T263P263c.787A>CMissense
RC400295 A289V289c.866C>TMissense
RC400296 T710I710c.2129C>TMissense
RC400297 G719S719c.2155G>AMissense
RC400298 G719C719c.2155G>TMissense
RC400299 G719A719c.2156G>CMissense
RC400300 E746_T751>A746c.2237_2251del15Deletion
RC400301 E746_S752>V746c.2237_2255AATTAAGAGAAGCAACATC>TDeletion
RC400302 K745_K750del745c.2235_2249del15deletion
RC400303 E746_S752>D746c.2238_2255del18deletion
RC400304 L747_S751del747c.2240_2254del15deletion
RC400305 L747_E749del747c.2239_2247del9deletion
RC400306 L747_P753>S747c.2240_2257del18deletion
RC400307 L747_A750>P747c.2239_2248TTAAGAGAAG>CDeletion
RC400308 L747_T751del747c.2239_2253del15deletion
RC400309 L815P815c.2444T>CMissense
RC400310 S784F784c.2351CC>TTMissense
RC400311 V769M769c.2305G>AMissense
RC400312 E872K872c.2614G>AMissense
RC400313 E866K866c.2596G>AMissense
RC400314 H835P835c.2504A>CMissense
RC400315 V769_D770insASV769c.2307_2308insGCCAGCGTGInsertion
RC400316 E709A709c.2126A>CMissense
RC400317 G598V598c.1793G>TMissense
RC400318 H773_V774insH773c.2319_2320insCACInsertion
RC400319 D770_N771insG770c.2310_2311insGGTInsertion
RC400320 L833V833c.2497T>GMissense
RC402760 R521K5211562G>AAlered rnsmembrne sinlin, ssoiion wih ?
RC402761 G796S7962386G>ASqumous ell rinom of hed & nek ?
RC402762 V843I8432527G>ALun ner

 

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