Description of the mutations of CDK4 (NM_000075) Mutants
Keys for Mutation Description
A.A. substitution
Truncation
NT deletion
NT insertion
Truncation
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted
| SKU | Mutation Description | Affected Codon# | Affected NT# | Description | Effect |
| RC401059 | R24H | 24 | 71 | G>A | Melnom |
| RC401060 | R24C | 24 | 70 | C>T | Melnom |
| RC401061 | N41S | 41 | 122 | A>G | Melnom |
| RC401062 | S52N | 52 | 155 | G>A | Melnom |
