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15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR?-mediated activation of p21WAF1/Cip1 Oncogene doi:10.1038/onc.2013.69 [PTGR2 ]
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene J. Biol. Chem., Apr 2013; 288: 12305 - 12312. [WDR85]
A New Signaling Pathway (JAK-Fes-phospholipase D) That Is Enhanced in Highly Proliferative Breast Cancer Cells J. Biol. Chem., Apr 2013; 288: 9881 - 9891. [FES]
Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells Cell Death and Disease 4, e607 doi:10.1038/cddis.2013.122 [GRP78]
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HomeAll Cancer Mutant ClonesALK Mutants

Description of the mutations of ALK (NM_004304) Mutants

Quote for the whole set

Keys for Mutation Description

A.A. substitution
Truncation
NT deletion
NT insertion
R280G: Arg at aa-position 280 mutated to Gly
R342X: R at aa-position 342 mutated to a stop codon and caused truncation of the protein
N268_D2: The deletion starts at nt#268. Two bases (including nt268) are deleted
N478-I6: The insertion starts after nt#478. Six bases are inserted

 

SKUMutation DescriptionAffected Codon#Affected NT#DescriptionEffect
RC400189 F1174L1174c.3520T>CMissense
RC400190 F1174I1174c.3520T>AMissense
RC400191 F1174V1174c.3520T>GMissense
RC400192 F1174C1174c.3521T>GMissense
RC400193 R1275Q1275c.3824G>AMissense
RC400194 T1211T1211c.3633C>AMissense
RC400195 I1171N1171c.3512T>AMissense
RC400196 F1245V1245c.3733T>GMissense
RC400197 F1245C1245c.3734T>GMissense
RC402696 T1087I10873260C>TNeuroblastoma
RC402697 G1128A11283383G>CNeuroblastoma
RC402698 T1151M11513452C>TNeuroblastoma
RC402699 R1192P11923575G>CNeuroblastoma

 

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