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Home TrueClone DYRK2 Clone

DYRK2 (NM_006482) Human Kinase Deficient Mutant

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC323580 DYRK2 (untagged)-Kinase deficient mutant (K251M) of Human dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2), transcript variant 2 (10ug), NM_006482.1, 10ug $680 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA309633 Rabbit Polyclonal DYRK2 Antibody, 0.1ml $325 3-7 Days
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Click here for the corresponding wild type clone.

OriGene Data
Vector:pCMV6-XL4 Insert Size: 2250 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseDruggable Genome
Reference Data
RefSeq: NM_006482.1, NP_006473
RefSeq Size: 3615 RefSeq ORF: 1806
Synonyms : FLJ21217; FLJ21365
LocusID: 8445 Cytogenetic: 12q15 Domains: pkinase, TyrKc, S_TKc
Summary: DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008].

Transcript Variant: This variant (2) includes the 149 bp insert in the 5' end of the transcript and thus results in a longer amino-terminal protein.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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