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Home TrueClone PPARD Clone

PPARD (NM_006238) Human cDNA Clone

Specifications Citations (1) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC127818 PPARD (untagged)-Human peroxisome proliferator-activated receptor delta (PPARD), transcript variant 1 (10ug), NM_006238.2, 10ug $660 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA317696 PPARD / PPAR Delta Rabbit anti-Mouse Polyclonal (Internal) Antibody, 50ug $345 3-7 Days
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OriGene Data
Vector:pCMV6-XL6 Insert Size: 4500 Restriction Site: NotI-NotI
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_006238.2.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Nuclear Hormone ReceptorTranscription FactorsDruggable Genome
Protein Pathways: PPAR signaling pathwayWnt signaling pathwayPathways in cancerAcute myeloid leukemia
Reference Data
RefSeq: NM_006238.2, NP_006229
RefSeq Size: 3328 RefSeq ORF: 1326
Synonyms : FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB
LocusID: 5467 Cytogenetic: 6p21.2 Domains: HOLI, ZnF_C4
Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan

Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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