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Home TrueClone BEST1 Clone

BEST1 (NM_004183) Human cDNA Clone

Specifications Citations (1) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC310242 BEST1 (untagged)-Human bestrophin 1 (BEST1), transcript variant 1 (10ug), NM_004183.2, 10ug $880 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA309586 Mouse Monoclonal Bestrophin 1 Antibody (E6-6), 0.1ml $325 3-7 Days
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OriGene Data
Vector:pCMV6-XL4 Insert Size: 1900 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Annotation: The ORF of this clone has been fully sequenced and found to contain one SNP compared to NM_004183.2.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Ion Channels: OtherTransmembraneDruggable Genome
Reference Data
RefSeq: NM_004183.2, NP_004174
RefSeq Size: 2673 RefSeq ORF: 1758
Synonyms : ARB; BEST; BMD; RP50; TU15B; VMD2
LocusID: 7439 Cytogenetic: 11q13 Domains: DUF289
Summary: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008].

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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