Caveolin 1 (CAV1) (NM_001753) Human Untagged Clone

CAT#: SC119082

CAV1 (untagged)-Human caveolin 1, caveolae protein, 22kDa (CAV1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Caveolin 1
• Synonyms: BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001172895 edited
  GAATTCGGCACGAGGCTCCTCACAGTTTTCATCCAGCCACGGGCCAGCATGTCTGGGGGC
  AAATACGTAGACTCGGAGGGACATCTCTACACCGTTCCCATCCGGGAACAGGGCAACATC
  TACAAGCCCAACAACAAGGCCATGGCAGACGAGCTGAGCGAGAAGCAAGTGTACGACGCG
  CACACCAAGGAGATCGACCTGGTCAACCGCGACCCTAAACACCTCAACGATGACGTGGTC
  AAGATTGACTTTGAAGATGTGATTGCAGAACCAGAAGGGACACACAGTTTTGACGGCATT
  TGGAAGGCCAGCTTCACCACCTTCACTGTGACGAAATACTGGTTTTACCGCTTGCTGTCT
  GCCCTCTTTGGCATCCCGATGGCACTCATCTGGGGCATTTACTTCGCCATTCTCTCTTTC
  CTGCACATCTGGGCAGTTGTACCATGCATTAAGAGCTTCCTGATTGAGATTCAGTGCATC
  AGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGACCCACTCTTTGAAGCTGTTGGG
  AAAATATTCAGCAATGTCCGCATCAACTTGCAGAAAGAAATATAAATGACATTTCAAGGA
  TAGAAGTATACCTGATTTTTTTTCCTTTTAATTTTCCTGTCAAGTTCCAAGTTGCTAATA
  CAGCAACAATTTATGAATTGAATTATCTTGGTTGAAAATAAAAAGATCACTTTCTCAGTT
  TTCATAAGTATTATGTCTCTTCTGAGCTATTTCATCTATTTTTGGCAGTCTGAATTTTTA
  AAACCCATTTAAATTTTTTTCCTTACCTTTTTATTTGCATGTGGATCAACCATCGCTTTA
  TTGGCTGAGATATGAACATATTGTTGAAAGGTAATTTGAGAGAAATATGAAGAACTGAGG
  AGGAAAAAAAAAAAAAAGAAAAGAACCAACAACCTCAACTGCCTACTCCAAAATGTTGGT
  CATTTTATGTTAAGGGAAGAATTCCAGGGTATGGCCATGGAGTGTACAAGTATGTGGGCA
  GATTTTCAGCAAACTCTTTTCCCACTGTTTAAGGAGTTAGTGGATTACTGCCATTCACTT
  CATAATCCAGTAGGATCCAGTGATCCTTACAAGTTAGAAAACATAATCTTCTGCCTTCTC
  ATGATCCAACTAATGCCTTACTCTTCTTGAAATTTTAACCTATGATATTTTCTGTGCCTG
  AATATTTGTTATGTAGATAACAAGACCTCAGTGCCTTCCTGTTTTTCACATTTTCCTTTT
  CAAATAGGGTCTAACTCAGCAACTCGCTTTAGGTCAGCAGCCTCCCTGAAGACCAAAATT
  AGAATATCCATGACCTAGTTTTCCATGCGTGTTTCTGACTCTGAGCTACAGAGTCTGGTG
  AAGCTCACTTCTGGGCTTCATCTGGCAACATCTTTATCCGTAGTGGGTATGGTTGACACT
  AGCCCAATGAAATGAATTAAAGTGGACCAATAGGGCTGAGCTCTCTGTGGGCTGGCAGTC
  CTGGAAGCCAGCTTTCCCTGCCTCTCATCAACTGAATGAGGTCAGCATGTCTATTCAGCT
  TCGTTTATTTTCAAGAATAATCACGCTTTCCTGAATCCAAACTAATCCATCACCGGGGTG
  GTTTAGTGGCTCAACATTGTGTTCCCATTTCAGCTGATCAGTGGGCCTCCAAGGAGGGGC
  TGTAAAATGGAGGCCATTGTGTGAGCCTATCAGAGTTGCTGCAAACCTGACCCCTGCTCA
  GTAAAGCACTTAAAAGATTGAAGTATTTTGCTGGAATAAGTTCAAATTCTTCTGAACTCA
  AACTGAGGAATTTCACCTGTAAACCTGAGTCGTACAGAAAGCTGCCTGGTATATCCAAAA
  GCTTTTTATTCCTCCTGCTCATATTGTGATTCTGCCTTTGGGGACTTTTCTTAAACCTTC
  AGTTATGATTTTTTTTTCATACACTTATTGGAACTCTGCTTGATTTTTGCCTCTTCCAGT
  CTTCCTGACACTTTAATTACCAACCTGTTACCTACTTTGACTTTTTGCATTTAAAACAGA
  CACTGGCATGGATATAGTTTTACTTTTAAACTGTGTACATAACTGAAAATGTGCTATACT
  GCATACTTTTTAAATGTAAAGATATTTTTATCTTTATATGAAGAAAATCACTTAGGAAAT
  GGCTTTGTGATTCAATCTGTAAACTGTGTATTCCAAGACATGTCTGTTCTACATAGATGC
  TTAGTCCCTCATGCAAATCAATTACTGGTCCAAAAGATTGCTGAAATTTTATATGCTTAC
  TGATATATTTTACAATTTTTTATCATGCATGTCCTGTAAAGGTTACAAGCCTGCACAATA
  AAAATGTTTAACGGTTAAAAAAAAAAAAAAAAAACTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001753 unedited
  TTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCTCCTCACAGTTTTC
  ATCCAGCCACGGGCCAGCATGTCTGGGGGCAAATACGTAGACTCGGAGGGACATCTCTAC
  ACCGTTCCCATCCGGGAACAGGGCAACATCTACAAGCCCAACAACAAGGCCATGGCAGAC
  GAGCTGAGCGAGAAGCAAGTGTACGACGCGCACACCAAGGAGATCGACCTGGTCAACCGC
  GACCCTAAACACCTCAACGATGACGTGGTCAAGATTGACTTTGAAGATGTGATTGCAGAA
  CCAGAAGGGACACACAGTTTTGACGGCATTTGGAAGGCCAGCTTCACCACCTTCACTGTG
  ACGAAATACTGGTTTTACCGCTTGCTGTCTGCCCTCTTTGGCATCCCGATGGCACTCATC
  TGGGGCATTTACTTCGCCATTCTCTCTTTCCTGCACATCTGGGCAGTTGTACCATGCATT
  AAGAGCTTCCTGATTGAGATTCAGTGCATCAGCCGTGTCTATTCCATCTACGTCCACACC
  GTTTGTGACCCACTCTTTGAAGCTGTTGGGAAAATATTCAGCAATGTCCGCATCACCTTG
  CAGAAAGAAATATAAATGACATTTTCAGGATAGAAGTATACCTGATTTTTTTTTCCTTTT
  AATCTTCCTGTCAAGTTCCAAGTTGCTAATACAGCAACAATTTATGAATTGAATTACCTC
  GGTTGAAAAAAAAAGATCACTTTCTCAGTTTTCATAAGAATTATGCTCTTCTGAGCTATT
  TCATCTATTTTGGGCAGCCTGAATTTTAAAACCCCATTAAATTTTTTCCCTTCCCTTTTT
  ATTTGAAGGGGGAACAACCATCCCTTTATTGGCTGGAGAAATCAACTACTGTGTGGAGAG
  TTATTTGGGCAAAATTTTGACAAACTGGGGAGGAAAAAAAAACAAGAAATGCAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001753 unedited
  ACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTAACCGTTAAACATTTT
  TATTGTGCAGGCTTGTAACCTTTACAGGACATGCATGATAAAAAATTGTAAAATATATCA
  GTAAGCATATAAAATTTCAGCAATCTTTTGGACCAGTAATTGATTTGCATGAGGGACTAA
  GCATCTATGTAGAACAGACATGTCTTGGAATACACAGTTTACAGATTGAATCACAAAGCC
  ATTTCCTAAGTGATTTTCTTCATATAAAGATAAAAATATCTTTACATTTAAAAAGTATGC
  AGTATAGCACATTTTCAGTTATGTACACAGTTTAAAAGTAAAACTATATCCATGCCAGTG
  TCTGTTTTAAATGCAAAAAGTCAAAGTAGGTAACAGGTTGGTAATTAAAGTGTCAGGAAG
  ACTGGAAGAGGCAAAAATCAAGCAGAGTTCCAATAAGTGTATGAAAAAAAAATCATAACT
  GAAGGTTTAAGAAAAGTCCCCAAAGGCAGAATCACAATATGAGCAGGAGGAATAAAAAGC
  TTTTGGATATACCAGGCAGCTTTCTGTACGACTCAGGTTTACAGGTGAAATTCCTCAGTT
  TGAGTTCAGAAGAATTTGAACTTATTCCAGCAAAATACTTCAATCTTTTAAGTGCTNTAC
  TGAGCANGGGTCANGGTTGCAGCAACTCTGATAGGCTCACACAATGGCCTNCATTTTACA
  GCCCCTCCTTGGNAGGCCACTGATCAGCTGAAATGGGAAACACATGNTGAGCCACTAAAC
  CACCCCGGTGATGGGATAGTTTGGATCAGGAAAGCGTGATTATTCTGAAAATAACGAGCT
  GAATAGACTGCTGACCTCATCANTGATGAGAGCAGGNAAAGCTGCTTNCAGATGNCAGCC
  ACAGAGAGCTAGCCTATGGNNCCTTNNATCATTCATGGGCTANGTCACCTCACACTACGA
  TAAGATGTGCGATGAGCCAAAGTGGACTACCAACTTTGTGCTAAGTCGAAACAGCTGAAA
  CTAGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001753
• Insert Size: 2400 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: A TrueClone.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001753.3, NP_001744.2
• RefSeq Size: 2704 bp
• RefSeq ORF: 537 bp
• Locus ID: 857
• UniProt ID: Q03135
• Cytogenetics: 7q31.2
• Domains: Caveolin
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Focal adhesion, Viral myocarditis
• Gene Summary: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
  Transcript Variant: This variant (1) encodes the longer isoform (alpha).