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Home TrueClone EP300 Clone

EP300 (NM_001429) Human cDNA Clone

Specifications Citations (0) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC128262 EP300 (untagged)-Human E1A binding protein p300 (EP300), NM_001429.2, 10ug $4350 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA309640 Mouse Monoclonal KAT3B/p300 Antibody (RW128), 0.2ml $325 In Stock
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OriGene Data
Vector:pCMV6-XL5 Insert Size: 10000 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence          3' Read Nucleotide Sequence         
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Transcription FactorsDruggable Genome
Protein Pathways: Cell cycleWnt signaling pathwayNotch signaling pathwayTGF-beta signaling pathwayAdherens junctionJak-STAT signaling pathwayMore Pathways >>
Reference Data
RefSeq: NM_001429.2, NP_001420
RefSeq Size: 8765 RefSeq ORF: 7245
Synonyms : KAT3B; p300; RSTS2
LocusID: 2033 Cytogenetic: 22q13.2 Domains: ZnF_TAZ, ZnF_ZZ, bromodomain, KIX
Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].


* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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