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Home TrueClone DAB2 Clone

DAB2 (NM_001343) Human cDNA Clone

Specifications Citations (2) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC321375 DAB2 (untagged)-Human disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (DAB2) (10ug) NM_001343.1, 10ug $185 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA307547 Rabbit monoclonal antibody against Dab2 (clone EPR2249 ), 100ul $325 3-7 Days
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OriGene Data
Vector:pCMV6-AC Insert Size: Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Druggable Genome
Protein Pathways: Endocytosis
Reference Data
RefSeq: NM_001343.1, NP_001334
RefSeq Size: 3268 RefSeq ORF: 2312
Synonyms : DOC-2; DOC2
LocusID: 1601 Cytogenetic: 5p13.1 Domains: PID
Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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