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Home TrueClone PDX1 Clone

PDX1 (NM_000209) Human cDNA Clone

Specifications Citations (3) Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC300025 PDX1 (untagged)-Human pancreatic and duodenal homeobox 1 (PDX1), NM_000209.1, 10ug $600 In Stock
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA500038 Pdx1 mouse monoclonal antibody, clone OTI2A12 (formerly 2A12), 100ul $325 In Stock
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OriGene Data
Vector: pCMV6-XL5 Insert Size: 900 Restriction Site:
Sequence Data: Fully Sequenced ORF          5' Read Nucleotide Sequence         
OTI Annotation: There are 2 nucleotide differences between the OriGene clone and the NCBI reference ORF, but these are silent and do not change the amino acid sequence of the deduced protein.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: ES Cell Differentiation/IPSEmbryonic stem cellsInduced pluripotent stem cellsTranscription Factors
Protein Pathways: Type II diabetes mellitusMaturity onset diabetes of the young
Reference Data
RefSeq Explanation: NM_000209.1, NP_000200
RefSeq Size: 1525 RefSeq ORF: 852
Synonyms : GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1
LocusID: 3651 Cytogenetic: 13q12.2
Gene Summary: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. [UniProtKB/Swiss-Prot Function]


* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping

 

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