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Over 1000 citations of OriGene cDNA clones
c-Jun and Ets2 Proteins Regulate Expression of Spleen Tyrosine Kinase in T Cells J. Biol. Chem., Apr 2012; 287: 11833 - 11841. [JUND ]
CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets J. Immunol., Apr 2012; 188: 3584 - 3593. [FCGR3A ]
Constitutive Expression of Inter-a-inhibitor (IaI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex J. Biol. Chem., Apr 2012; 287: 12433 - 12444. [TNFAIP6 ]
Developmental Endothelial Locus-1 (Del-1) Mediates Clearance of Platelet Microparticles by the Endothelium Circulation, Apr 2012; 125: 1664 - 1672. [EDIL3 ]
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FGFR2 (BC039243) Human Kinase Deficient Mutant

Specifications Clones of Other Species Product Manual FAQs
Cat. No. Ref. ID Description Amount Price Shipping  
SC323649 BC039243 Kinase deficient mutant (K535M) of Homo sapiens, Similar to fibroblast growth factor receptor 2 as transfection- BC039243.1 10ug $580 Next day Add to Shopping Cart
Click here for the corresponding wild type clone.
    


OriGene Data
Vector:pCMV6-XL4 Insert Size: 3900 Restriction Site:
Sequence Data: 5' Read Nucleotide Sequence          Kinase domain sequence
OTI Annotation: This kinase-deficient mutant clone was generated by created by site-directed mutagenesis from the corresponding wild-type clone. See details in "Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling." Cell. 2008 May p536-548.
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: Protein KinaseSecreted ProteinTransmembraneDruggable Genome
Protein Pathways: MAPK signaling pathwayEndocytosisRegulation of actin cytoskeletonPathways in cancerProstate cancer
Reference Data
RefSeq: BC039243.1, AAH39243
 RefSeq Size: 3575 RefSeq ORF: 2172
Synonyms : TK25;soluble FGFR4 variant 4; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FLJ98662; JWS; K-SAM; KGFR; TK14; BEK fibroblast growth factor receptor; FGF receptor; OTTHUMP00000020621; OTTHUMP00000020629; bacteria-expressed kinase; hydroxyaryl-protein kinase; kerat
LocusID: 2263 Cytogenetic: 10q26
Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq].


Insert Size determined experimentally by digestion of the clone with Not I restriction enzyme

 

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