Cyclin E1 (CCNE1) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Applications | ELISA, IP, WB |
Recommended Dilution | ELISA: 1:2,000. Immunoprecipitation. Western Blot: 1:200 to 1:500. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Full length synthetic polypeptide corresponding to the human gene sequence. |
Specificity | This product was prepared from monospecific antiserum by delipidation and defibrination. Antiserum will specifically react with a 45 kDa Cyclin E protein. No reaction was observed against other related cyclins. Cross reactivity with Cyclin E from other species may also occur. |
Formulation | State: Serum State: Liquid serum containing 0.01% Sodium Azide |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: 6 month from despatch. |
Gene Name | cyclin E1 |
Database Link | |
Background | Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers. |
Synonyms | Cyclin-E1, CCNE1, CCNE |
Reference Data |
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