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Home cDNA Clone Mutant & Variant Clones

Disease Mutant and Variant Clones

Beyond the standard reference sequences
Mutant Clone

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Variant cDNA clones are important for biomedical research. They bear slight difference than the reference cDNA clones. Naturally occurring variants are important for molecular diagnosis and biomarker discovery. Researchers routinely design variants of a gene to test the functional relevance of each segment

OriGene offers some of the ready-made variant clones to facilitate such research.

Currently the offering includes:

Description # of Mutants Reference
Kinase-deficient (kinase-dead) mutants 345 Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell. 2008 May p536-548.
ACVR1 mutants 9 Kaplan (2009) Hum Mutat 30, 379
AKT1 mutants 2
ALK mutants 13 Chen (2008) Nature 455, 971
AMHR2 mutants 9 Imbeud (1996) Hum Mol Gene 5, 1269
AURKA mutants 3 Greenman (2007) Nature 446, 153
AURKC mutants 1 Greenmn (2007) Nure 446, 153
AXIN1 mutants 5
AXIN2 mutants 3
BCL2 mutants 1 Komki (1998) Hum Gene 103, 435
BRAF mutants 43 Schulz (2008) Clin Genet 73, 62
BRCA1 mutants 388 Hansen (2009) Breast Canceres Treat 115, 69
BRCA2 mutants 273 de Juan (2009) Breast Canceres Treat 115, 405
BTK mutants 291 Lee (2011) Asin P J Allery Immunol 29, 260
BUB1B mutants 10 Msuur (2006) Am J Med Gene A 140A, 358
CBL mutants 24
CBLB mutants 5 Yokoi (2008) Biochem Biophys Res Commun 368, 37
CDH1 mutants 8
CDK4 mutants 4 Hollnd (1999) Genes Chromosomes Cner 25, 339
CDK7 mutants 1 Greenmn (2007) Nure 446, 153
CDKN1B mutants 4 Pellegata (2006) Proc Natl Acad Sci U S A 103, 15558
CDKN1C mutants 10 Percesepe (2008) Prenat Diagn 28, 447
CDKN2A mutants 24
CSF1R mutants 1 Ridge (1990) Proc Natl Acad Sci U S A 87, 1377
CTNNB1 mutants 46 Fearnhead (2004) Proc Natl Acad Sci U S A 101, 15992
DDR2 mutants 3 Brl (2009) Am J Hum Gene 84, 80
EGFR mutants 39 Shwenner (2008) Hed Nek 30, 1040
EPHA2 mutants 1 Shiels (2008) Mol Vis 14, 2042
EPHX1 mutants 4 Svs (2006) Hum Genomis 2, 274
ERBB2 mutants 1 Xie (2000) J Natl Cancernst 92, 412
ERCC2 mutants 37 Bo (2009) Hum Mu 30, 438
FGFR1 mutants 53 Dode (2007) Hum Mutat 28, 97
FGFR4 mutants 1 Bange (2002) Canceres 62, 840
FH mutants 60 Bdeloe (2008) J Dermol Si 51, 139
FLT3 mutants 1 Schnittger (2006) Genes Chromosomes Cancer5, 332
FLT4 mutants 33 Connell (2009) Hum Genet 124, 625
FRK mutants 1 Greenman (2007) Nature 446, 153
GATA1 mutants 6 Phillips (2007) Blood 109, 2618
GCK mutants 249 Cappelli (2009) Diabetes Res Clin Pract 83, e72
GNAS mutants 47 Freson (2008) J Clin Endorinol Meb 93, 4851
GPC3 mutants 11 Penisson-Besnier (2008) Am J Med Gene A 146A, 464
GRK1 mutants 10 Jin (2008) J Med Gene 45, 465
GRK4 mutants 3 Benr (2002) Clin Chem 48, 2131
GRK5 mutants 1 Liggett (2008) Nat Med 14, 510
HIF1A mutants 2 Ollerenshaw (2004) Cancerenet Cytogenet 153, 122
HOXB13 mutants 2
HRAS mutants 24 Lo (2008) J Med Gene 45, 167
IDH1 mutants 5 Yan (2009) N. Engl. J. Med., 360: 765 - 773
IDH2 mutants 3 Yan (2009) N. Engl. J. Med., 360: 765 - 773
ILK mutants 1 Knoll (2007) Cirulion 116, 515
IRAK1 mutants 1 Yamada (2008) Stroke 39, 2211
JAG2 mutants 1 Vieira (2005) PLoS Genet 1, e64
KRAS mutants 21 Gremer (2011) Hum. Mutat. 32:33-43
LPAR6 mutants 7 Azeem (2008) Hum Gene 123, 515
LTK mutants 1 Li (2004) Hum Mol Gene 13, 171
LYN mutants 1 Greenman (2007) Nature 446, 153
MAF mutants 3 Hansen (2007) Mol Vis 13, 2019
MAP2K1 mutants 10 Schulz (2008) Clin Genet 73, 62
MAP2K2 mutants 12 Nysrom (2008) J Med Gene 45, 500
MASTL mutants 1 Gndhi (2003) Hum Hered 55, 66
MEN1 mutants 237 Peppa (2009) Clin Endocrinol (Oxf) 70, 75
MERTK mutants 6 Tada (2006) Mol Vis 12, 441
MET mutants 9
MLH1 mutants 233 Shen (2008) Cyoene Genome Res 122, 22
MPL mutants 4
MSH2 mutants 212 Prk (2008) Cner Gene Cyoene 182, 136
MSH6 mutants 83 Devlin (2008) Ulser Med J 77, 25
MST1R mutants 1 Greenmn (2007) Nure 446, 153
MYBL2 mutants 2 Shwb (2008) Onoene 27, 2929
MYC mutants 2 Wirtenberger (2005) Int J Cancer17, 638
MYCN mutants 11 Marcelis (2008) Hum Mutat 29, 1125
MYO3A mutants 1 Walsh (2002) Proc Natl Acad Sci U S A 99, 7518
NF2 mutants 87 Ahronowiz (2007) Hum Mu 28, 1
NOTCH3 mutants 156 Ungaro (2008) Hum Genet 123 555
NRAS mutants 17 Gambke (1985) PNAS 1985, 82: 879-882
PAK3 mutants 4 Peippo (2007) Am J Med Genet A 143A, 2406
PASK mutants 1 Greenman (2007) Nature 446, 153
PIK3C2G mutants 1 Dimon (2008) Biohem Biophys Res Commun 365, 466
PIK3CA mutants 67
PKN3 mutants 1 Greenmn (2007) Nure 446, 153
PRKCG mutants 21 Nolte (2007) Mov Disord 22, 265
PRKCH mutants 1 Kubo (2007) Nat Genet 39, 212
PRKDC mutants 1 van der Burg (2008) J Clin Invest 119, 94
PTEN mutants 43
RAF1 mutants 18 Ko (2008) J Hum Genet 53, 999
RASSF1 mutants 1 Kanzaki (2006) Cancerett 238, 128
RB1 mutants 5
RET mutants 179 Chin (2008) J Chin Med Assoc 71, 406
ROR2 mutants 16 Ali (2007) Hum Genet 122, 389
RYK mutants 1 Watanabe (2006) Cleft Palate Craniofac J 43, 310
SERPIND1 mutants 3 Corral (2004) Circulation 110, 1303
STAT1 mutants 4 Chpier (2006) PLoS Gene 2, 1193
STK11 mutants 82 Scott (2008) Hum Genet 124 300
TEK mutants 2 Calvert (1999) Hum Mol Genet 8, 1279
TERT mutants 30 Calado (2009) Proc Natl Acad Sci U S A 106, 1187
TNNI3K mutants 1 Greenman (2007) Nature 446, 153
TP53 mutants 95 Adhem (2010) J. Pathol. 221: 49-56
TSC2 mutants 240 Hirfnolu (2010) Pedir Neurol 42, 343
TYK2 mutants 4 Tomsson (2008) Blood 111, 4797
WT1 mutants 62 Regev (2008) Am J Med Genet A 146A, 2332
XRCC1 mutants 4 Jorensen (2009) Cner Epidemiol Biomrkers Prev 18, 346
ZAP70 mutants 5 Elder (2001) J Immunol 166, 656

OriGene also offers gene synthesis service for any mutant clone construction.

 

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