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Over 1000 citations of OriGene cDNA clones
Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell–Mediated Tumor Killing and Memory Responses Cancer Prevention Research, Jan 2012; 5: 122 - 137. [HSPB1 ]

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells Mol. Cancer Res., Jan 2012; 10: 133 - 142. [SREBF1 ]

Androgen Deprivation Causes Epithelial–Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy Cancer Res., Jan 2012; 72: 527 - 536. [AR ]

CB2 Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling J. Biol. Chem., Jan 2012; 287: 1198 - 1209. [Cnr2 ]

View All Citations >>

 

Disease Mutant and Variant Clones

Beyond the standard reference sequences

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Variant cDNA clones are important for biomedical research. They bear slight difference than the reference cDNA clones. Naturally occurring variants are important for molecular diagnosis and biomarker discovery. Researchers routinely design variants of a gene to test the functional relevance of each segment

OriGene offers some of the ready-made variant clones to facilitate such research.

Currently the offering includes:

Description # of Mutants Reference
Kinase-deficient (kinase-dead) mutants 345 Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell. 2008 May p536-548.
HRAS mutants 12 Germline mutations in HRAS proto-oncogene cause Costello syndrome Nat. Genet. 2005; 37:1038-1040
The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma Int. J. Cancer 1992; 52:867-872
IDH1 mutants 5 IDH1 and IDH2 Mutations in Gliomas N. Engl. J. Med., Feb 2009; 360: 765 - 773.
IDH2 mutants 3 IDH1 and IDH2 Mutations in Gliomas N. Engl. J. Med., Feb 2009; 360: 765 - 773.
KRAS mutants 21 Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum. Mutat. 2011; 32:33-43
BRAF and KRAS mutations in stomach cancer Oncogene 2003; 22:6942-6945
NRAS mutants 17 Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon Proc. Natl. Acad. Sci. U.S.A. 1985; 82:879-882
TP53 mutants 95 95 Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary J. Pathol. 2010; 221: 49-56
OriGene also offers gene synthesis service for any mutant clone construction.

 

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