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Over 1000 citations of OriGene cDNA clones
c-Jun and Ets2 Proteins Regulate Expression of Spleen Tyrosine Kinase in T Cells J. Biol. Chem., Apr 2012; 287: 11833 - 11841. [JUND ]

CD16 Regulates TRIF-Dependent TLR4 Response in Human Monocytes and Their Subsets J. Immunol., Apr 2012; 188: 3584 - 3593. [FCGR3A ]

Constitutive Expression of Inter-a-inhibitor (IaI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex J. Biol. Chem., Apr 2012; 287: 12433 - 12444. [TNFAIP6 ]

Developmental Endothelial Locus-1 (Del-1) Mediates Clearance of Platelet Microparticles by the Endothelium Circulation, Apr 2012; 125: 1664 - 1672. [EDIL3 ]

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Disease Mutant and Variant Clones

Beyond the standard reference sequences

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Variant cDNA clones are important for biomedical research. They bear slight difference than the reference cDNA clones. Naturally occurring variants are important for molecular diagnosis and biomarker discovery. Researchers routinely design variants of a gene to test the functional relevance of each segment

OriGene offers some of the ready-made variant clones to facilitate such research.

Currently the offering includes:

Description # of Mutants Reference
Kinase-deficient (kinase-dead) mutants 345 Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell. 2008 May p536-548.
 mutants
BRAF mutants 7
HRAS mutants 12 Germline mutations in HRAS proto-oncogene cause Costello syndrome Nat. Genet. 2005; 37:1038-1040
The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma Int. J. Cancer 1992; 52:867-872
IDH1 mutants 5 IDH1 and IDH2 Mutations in Gliomas N. Engl. J. Med., Feb 2009; 360: 765 - 773.
IDH2 mutants 3 IDH1 and IDH2 Mutations in Gliomas N. Engl. J. Med., Feb 2009; 360: 765 - 773.
KRAS mutants 21 Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. Hum. Mutat. 2011; 32:33-43
BRAF and KRAS mutations in stomach cancer Oncogene 2003; 22:6942-6945
NRAS mutants 17 Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon Proc. Natl. Acad. Sci. U.S.A. 1985; 82:879-882
TP53 mutants 95 95 Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary J. Pathol. 2010; 221: 49-56
OriGene also offers gene synthesis service for any mutant clone construction.

 

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