Variant cDNA clones are important for biomedical research. They bear slight difference than the reference cDNA clones. Naturally occurring variants are important for molecular diagnosis and biomarker discovery. Researchers routinely design variants of a gene to test the functional relevance of each segment
OriGene offers some of the ready-made variant clones to facilitate such research.
Description
# of Mutants
Reference
Kinase-deficient (kinase-dead) mutants
345 Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell. 2008 May p536-548 .
ACVR1 mutants9 Kaplan (2009) Hum Mutat 30, 379
AKT1 mutants2
ALK mutants13 Chen (2008) Nature 455, 971
AMHR2 mutants9 Imbeud (1996) Hum Mol Gene 5, 1269
AURKA mutants3 Greenman (2007) Nature 446, 153
AURKC mutants1 Greenmn (2007) Nure 446, 153
AXIN1 mutants5
AXIN2 mutants3
BCL2 mutants1 Komki (1998) Hum Gene 103, 435
BRAF mutants43 Schulz (2008) Clin Genet 73, 62
BRCA1 mutants388 Hansen (2009) Breast Canceres Treat 115, 69
BRCA2 mutants273 de Juan (2009) Breast Canceres Treat 115, 405
BTK mutants291 Lee (2011) Asin P J Allery Immunol 29, 260
BUB1B mutants10 Msuur (2006) Am J Med Gene A 140A, 358
CBL mutants24
CBLB mutants5 Yokoi (2008) Biochem Biophys Res Commun 368, 37
CDH1 mutants8
CDK4 mutants4 Hollnd (1999) Genes Chromosomes Cner 25, 339
CDK7 mutants1 Greenmn (2007) Nure 446, 153
CDKN1B mutants4 Pellegata (2006) Proc Natl Acad Sci U S A 103, 15558
CDKN1C mutants10 Percesepe (2008) Prenat Diagn 28, 447
CDKN2A mutants24
CSF1R mutants1 Ridge (1990) Proc Natl Acad Sci U S A 87, 1377
CTNNB1 mutants46 Fearnhead (2004) Proc Natl Acad Sci U S A 101, 15992
DDR2 mutants3 Brl (2009) Am J Hum Gene 84, 80
EGFR mutants39 Shwenner (2008) Hed Nek 30, 1040
EPHA2 mutants1 Shiels (2008) Mol Vis 14, 2042
EPHX1 mutants4 Svs (2006) Hum Genomis 2, 274
ERBB2 mutants1 Xie (2000) J Natl Cancernst 92, 412
ERCC2 mutants37 Bo (2009) Hum Mu 30, 438
FGFR1 mutants53 Dode (2007) Hum Mutat 28, 97
FGFR4 mutants1 Bange (2002) Canceres 62, 840
FH mutants60 Bdeloe (2008) J Dermol Si 51, 139
FLT3 mutants1 Schnittger (2006) Genes Chromosomes Cancer5, 332
FLT4 mutants33 Connell (2009) Hum Genet 124, 625
FRK mutants1 Greenman (2007) Nature 446, 153
GATA1 mutants6 Phillips (2007) Blood 109, 2618
GCK mutants249 Cappelli (2009) Diabetes Res Clin Pract 83, e72
GNAS mutants47 Freson (2008) J Clin Endorinol Meb 93, 4851
GPC3 mutants11 Penisson-Besnier (2008) Am J Med Gene A 146A, 464
GRK1 mutants10 Jin (2008) J Med Gene 45, 465
GRK4 mutants3 Benr (2002) Clin Chem 48, 2131
GRK5 mutants1 Liggett (2008) Nat Med 14, 510
HIF1A mutants2 Ollerenshaw (2004) Cancerenet Cytogenet 153, 122
HOXB13 mutants2
HRAS mutants24 Lo (2008) J Med Gene 45, 167
IDH1 mutants5 Yan (2009) N. Engl. J. Med., 360: 765 - 773
IDH2 mutants3 Yan (2009) N. Engl. J. Med., 360: 765 - 773
ILK mutants1 Knoll (2007) Cirulion 116, 515
IRAK1 mutants1 Yamada (2008) Stroke 39, 2211
JAG2 mutants1 Vieira (2005) PLoS Genet 1, e64
KRAS mutants21 Gremer (2011) Hum. Mutat. 32:33-43
LPAR6 mutants7 Azeem (2008) Hum Gene 123, 515
LTK mutants1 Li (2004) Hum Mol Gene 13, 171
LYN mutants1 Greenman (2007) Nature 446, 153
MAF mutants3 Hansen (2007) Mol Vis 13, 2019
MAP2K1 mutants10 Schulz (2008) Clin Genet 73, 62
MAP2K2 mutants12 Nysrom (2008) J Med Gene 45, 500
MASTL mutants1 Gndhi (2003) Hum Hered 55, 66
MEN1 mutants237 Peppa (2009) Clin Endocrinol (Oxf) 70, 75
MERTK mutants6 Tada (2006) Mol Vis 12, 441
MET mutants9
MLH1 mutants233 Shen (2008) Cyoene Genome Res 122, 22
MPL mutants4
MSH2 mutants212 Prk (2008) Cner Gene Cyoene 182, 136
MSH6 mutants83 Devlin (2008) Ulser Med J 77, 25
MST1R mutants1 Greenmn (2007) Nure 446, 153
MYBL2 mutants2 Shwb (2008) Onoene 27, 2929
MYC mutants2 Wirtenberger (2005) Int J Cancer17, 638
MYCN mutants11 Marcelis (2008) Hum Mutat 29, 1125
MYO3A mutants1 Walsh (2002) Proc Natl Acad Sci U S A 99, 7518
NF2 mutants87 Ahronowiz (2007) Hum Mu 28, 1
NOTCH3 mutants156 Ungaro (2008) Hum Genet 123 555
NRAS mutants17 Gambke (1985) PNAS 1985, 82: 879-882
PAK3 mutants4 Peippo (2007) Am J Med Genet A 143A, 2406
PASK mutants1 Greenman (2007) Nature 446, 153
PIK3C2G mutants1 Dimon (2008) Biohem Biophys Res Commun 365, 466
PIK3CA mutants67
PKN3 mutants1 Greenmn (2007) Nure 446, 153
PRKCG mutants21 Nolte (2007) Mov Disord 22, 265
PRKCH mutants1 Kubo (2007) Nat Genet 39, 212
PRKDC mutants1 van der Burg (2008) J Clin Invest 119, 94
PTEN mutants43
RAF1 mutants18 Ko (2008) J Hum Genet 53, 999
RASSF1 mutants1 Kanzaki (2006) Cancerett 238, 128
RB1 mutants5
RET mutants179 Chin (2008) J Chin Med Assoc 71, 406
ROR2 mutants16 Ali (2007) Hum Genet 122, 389
RYK mutants1 Watanabe (2006) Cleft Palate Craniofac J 43, 310
SERPIND1 mutants3 Corral (2004) Circulation 110, 1303
STAT1 mutants4 Chpier (2006) PLoS Gene 2, 1193
STK11 mutants82 Scott (2008) Hum Genet 124 300
TEK mutants2 Calvert (1999) Hum Mol Genet 8, 1279
TERT mutants30 Calado (2009) Proc Natl Acad Sci U S A 106, 1187
TNNI3K mutants1 Greenman (2007) Nature 446, 153
TP53 mutants95 Adhem (2010) J. Pathol. 221: 49-56
TSC2 mutants240 Hirfnolu (2010) Pedir Neurol 42, 343
TYK2 mutants4 Tomsson (2008) Blood 111, 4797
WT1 mutants62 Regev (2008) Am J Med Genet A 146A, 2332
XRCC1 mutants4 Jorensen (2009) Cner Epidemiol Biomrkers Prev 18, 346
ZAP70 mutants5 Elder (2001) J Immunol 166, 656
OriGene also offers gene synthesis service for any mutant clone construction.
