OriGene - BEST3 (NM_152439) cDNA Clone

OriGene Data

Vector:	pCMV6-XL5	Insert Size: 3180	Restriction Site: NotI-NotI
Sequence Data:	5' Read Nucleotide Sequence 3' Read Nucleotide Sequence
OTI Disclaimer:	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components:	The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families:	Ion Channels: Other Transmembrane
Protein Pathways:

Reference Data

RefSeq: NM_152439.1, NP_689652	RefSeq Size: 2912	RefSeq ORF: 807
Synonyms : VMD2L3
LocusID: 144453	Cytogenetic: 12q14.2
Summary: BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]. Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.

TrueClone Citations:

Dihydrotestosterone and Bicalutamide Do Not Affect Periostin Expression in Androgen-dependent LNCaP Prostate Cancer Cell Lines, FRANCESCA ARGELLATI, PIER VITALE NUZZO, FRANCESCO RICCI, ROSA MANGERINI, ALESSANDRA RUBAGOTTI, and FRANCESCO BOCCARDO, Anticancer Res, Mar 2013; 33: 815 - 820. [POSTN]

An SRF/miR-1 axis regulates NCX1 and Annexin A5 protein levels in the normal and failing heart, Eva Tritsch, Youssef Mallat, Florence Lefebvre, Nicolas Diguet, Brigitte Escoubet, Jocelyne Blanc, Leon J. De Windt, Daniele Catalucci, Grégoire Vandecasteele, Zhenlin Li, and Mathias Mericskay, Cardiovasc Res, Mar 2013; 10.1093/cvr/cvt042. [JunD]

CSF1R mutations link POLD and HDLS as a single disease entity, Alexandra M. Nicholson, Matt C. Baker, NiCole A. Finch, Nicola J. Rutherford, Christian Wider, Neill R. Graff-Radford, Peter T. Nelson, H. Brent Clark, Zbigniew K. Wszolek, Dennis W. Dickson, David S. Knopman, and Rosa Rademakers, Neurology, Mar 2013; 80: 1033 - 1040. [CSF1R ]

Induced CYP3A4 Expression in Confluent Huh7 Hepatoma Cells as a Result of Decreased Cell Proliferation and Subsequent Pregnane X Receptor Activation, Louise Sivertsson, Irene Edebert, Margareta Porsmyr Palmertz, Magnus Ingelman-Sundberg, and Etienne P. A. Neve, Mol. Pharmacol., Mar 2013; 83: 659 - 670. [NR1I2 ]

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members, Alexis Verger, Jean-Luc Baert, Kathye Verreman, Frédérique Dewitte, Elisabeth Ferreira, Zoé Lens, Yvan de Launoit, Vincent Villeret, and Didier Monté, Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt199. [MED25]

Centaurin-a1-Ras-Elk-1 Signaling at Mitochondria Mediates ß-Amyloid-Induced Synaptic Dysfunction, Erzsebet M. Szatmari, Ana F. Oliveira, Elizabeth J. Sumner, and Ryohei Yasuda, J. Neurosci., Mar 2013; 33: 5367 - 5374. [APP]

Activation of the Ca2+-sensing receptor increases renal claudin-14 expression and urinary Ca2+ excretion, Henrik Dimke, Prajakta Desai, Jelena Borovac, Alyssa Lau, Wanling Pan, and R. Todd Alexander, Am J Physiol Renal Physiol, Mar 2013; 304: F761 - F769. [Cldn14]

Mechanisms by which the orexigen NPY regulates anorexigenic a-MSH and TRH, Nicole E. Cyr, Anika M. Toorie, Jennifer S. Steger, Matthew M. Sochat, Samantha Hyner, Mario Perello, Ronald Stuart, and Eduardo A. Nillni, Am J Physiol Endocrinol Metab, Mar 2013; 304: E640 - E650. [NYP1R]

Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway, David R. Croucher, Falko Hochgräfe, Luxi Zhang, Ling Liu, Ruth J. Lyons, Danny Rickwood, Carole M. Tactacan, Brigid C. Browne, Naveid Ali, Howard Chan, Robert Shearer, David Gallego-Ortega, Darren N. Saunders, Alexander Swarbrick, and Roger J. Daly, Cancer Res., Mar 2013; 73: 1969 - 1980. [SGK269 ]

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BEST3 Mouse Clones

SKU	Description	Amount	Price	Shipping
MC220299	Mus musculus bestrophin 3 (Best3) as transfection-ready DNA	10 ug	$800	5 weeks
MR220298	Myc-DDK-tagged ORF clone of Mus musculus bestrophin 3 (Best3) as transfection-ready DNA	10 ug	$800	5 weeks
MG220298	GFP-tagged ORF clone of Mus musculus bestrophin 3 (Best3) as transfection-ready DNA	10 ug	$880	3 weeks

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BEST3 (NM_152439) Human cDNA Clone

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