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Home TrueClone BACE1 Clone

BACE1 (NM_138973) Human cDNA Clone

Specifications Citations Clones of Other Species Product Documents
SKU Description Price Availibility*  
SC313437 BACE1 (untagged)-Human beta-site APP-cleaving enzyme 1 (BACE1), transcript variant d, NM_138973.3, 10ug $670 3 weeks
TF81001 TurboFectin, High performance Transfection reagent (1ml/vial) $420 In Stock
TA306033 Rabbit Polyclonal BACE Antibody, 100ug $325 In Stock
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OriGene Data
Vector: pCMV6-Entry QM Insert Size: Restriction Site: SgfI-MluI
Sequence Data: Fully Sequenced ORF         
OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA
OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Protein Families: TransmembraneProteaseDruggable Genome
Protein Pathways: Alzheimer's disease
Reference Data
RefSeq Explanation: NM_138973.3, NP_620429
RefSeq Size: 5657 RefSeq ORF: 1299
Synonyms : ASP2; BACE; HSPC104
LocusID: 23621 Cytogenetic: 11q23.2-q23.3 Domains: asp
Gene Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015].

Transcript Variant: This variant (d) has an alternate splice junction in the coding region, compared to variant a. The resulting isoform (D) lacks an internal segment, compared to isoform A.

* Delivery time is an estimate in business days. Occasional delays may occur due to unforeseen complexities in the preparation of your construct. International customers may expect an additional 1-2 weeks in shipping


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